Our body releases digestive enzymes and begins the digestive process when we eat food. When you take a supplement (pill/capsule), the body does not recognize it as food, and often does not properly digest it.
If you take supplements along with something to eat or drink, then you are much more likely to get the benefit of them.
I don’t see why it would make any difference between taking a variety of supplements than eating a variety of foods ?
If you need to take medications at a different time, then just have something small to drink along with it. I have to take my heart medication morning and evening, and I have a cup of coffee with heavy cream in the morning with my meds, and since my OMAD meal is usually early afternoon, I am still digesting the protein at night, and the meds will go right in with that digestion.
Even though a tiny bit of food can stop autophagy, it is not likely to stop a person from losing weight and getting healthy, and it will help your supplements to be used by your body.