One of the things that I read is that our body recognizes when we are eating food, and it then produces the natural acids and digestive enzymes that we need for our body to digest and utilize the food we eat. However, when we are only swallowing vitamin capsules, our body does not see that as food, and that is why so many times, vitamins are not digested, and even can pass through our body completely intact.
What I do, is take my first vitamins and heart meds with a cup of coffee with a dab of cream, and I do this when I first get up in the morning.
The evening supplements, I do take with just water, but i still have food in my stomach that is being digested from my afternoon OMAD meal; so I believe that they will simply be digested along with the rest of that meal, during the night.
If I were only going to take supplements once, then I would do it along with my meal for the day, or at least sometime close after I had eaten.
I know that my cup of coffee with cream does break the fast from overnight, but it is not like having a whole breakfast meal, and it allows me something to help utilize my supplements.
As long as it is working for me, I will continue to take my first supplements with my morning coffee, in hopes that they are digesting better this way. I think that each person just has to try different things and see what does or does not work for them. If not breaking the fast is really important to you, then taking all of your supplements at once, along with your meal, would probably work best.